Welcome to The Xu Research Group
Our research aims to develop innovative synthetic methodologies and therapeutic approaches, and apply them to solving pressing problems of biological and medical importance. New synthetic methodologies and strategies (e.g. non-traditional disconnections and C–H functionalization) have great impacts on the discovery of transformational medicines by enabling the rapid and efficient synthesis of novel, diverse, and complex biologically active molecules. New therapeutic approaches (e.g. targeted covalent inhibition and targeted protein degradation) provide new opportunities to address traditionally “undruggable” disease targets. We combine these efforts to achieve the research goal of identifying small-molecule probes and drug candidates that specifically remove/inhibit disease-causing proteins in cells and animal models and ultimately impact human health.
Research
Small-Molecule Approaches to Targeted Protein Degradation for Drug Discovery
Late-Stage Functionalization and Its Medical Applications
Organoboron Chemistry and Its Medical Applications
--- Group News ---
2023-01-01
